• Nitric Oxide Precursors and Dimethylarginines as Risk Markers for Accelerated Measured GFR Decline in the General Population 

      Rinde, Nikoline Balteskard; Enoksen, Inger Therese Tønsberg; Melsom, Toralf; Fuskevåg, Ole Martin; Eriksen, Bjørn Odvar; Norvik, Jon Viljar Porserud (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-19)
      Introduction: Nitric oxide (NO) deficiency is associated with endothelial dysfunction, hypertension, atherosclerosis, and chronic kidney disease (CKD). Reduced NO bioavailability is hypothesized to play a vital role in kidney function impairment and CKD. We investigated the association of serum levels of endogenous inhibitors of NO, asymmetric dimethylarginine (ADMA) and symmetric dimethylargin ...
    • Validation of eGFR for Detecting Associations Between Serum Protein Biomarkers and Subsequent GFR Decline 

      Enoksen, Inger Therese Tønsberg; Rinde, Nikoline Balteskard; Svistounov, Dmitri; Norvik, Jon Viljar Porserud; Solbu, Marit Dahl; Eriksen, Bjørn Odvar; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08)
      Significance Statement - eGFR from creatinine, cystatin C, or both has been primarily used in search of biomarkers for GFR decline. Whether the relationships between biomarkers and eGFR decline are similar to associations with measured GFR (mGFR) decline has not been investigated. This study revealed that some biomarkers showed statistically significant different associations with eGFR decline ...